This dual action is one reason tirzepatide may support stronger results for some patients compared with GLP-1 treatment alone
Magnesium deficiency is also possibly related to lower serotonin levels, so improving your magnesium levels, which antidepressants often do in the brain, may increase the feel-good chemical in the brain
For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%
Nevertheless, when analyses were adjusted for BMI, level of physical activity, number of somatic comorbidities, smoking status and alcohol use, results were substantially unchanged