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Among other things, these mediators influence TRP ion channels, which is important for pain relief (in lipoedema, ~80 % of those affected suffer from pain)

Additionally, data indicate that women with previous neural tube defect (NTD) affected pregnancies should increase their folic acid intake to 4 mg/day PO during the period of greatest risk (1 month before and the 3 months after conception)

Research shows that carnosine supplementation increases muscle carnosine content by up to 80%, enhances muscle buffer capacity by 45%, and significantly reduces exercise-induced acidosis markers

They kind of hit a bunch of articles and give you an update on what they found, but very general, very vague