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Below are the most clinically important agents and what the data show
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observed that REE exposure was associated with increased mutation frequencies in key driver genes (EGFR, TP53, KR), with stronger effects in female patients, suggesting potential sex-specific genotoxicity (81)
therefore, in vivo studies in SCD mice to demonstrate in more detail a physiological significance of the TSS pathway in alleviating oxidative and ferroptosis stress are warranted
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