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Side effects and safety warnings Patients taking semaglutide report experiencing gastrointestinal-related side effects, including vomiting, nausea, diarrhea, constipation, headache, and fatigue

Common side effects may include: Mild injection-site reactions (redness, soreness, itching) Upset stomach or nausea Headache Mild anxiety or restlessness Rarely, allergic reactions If you experience difficulty breathing, severe dizziness, or hives, seek medical attention immediately

Clinically, however, the evidence is mixed : Vitamin B12 has a well-established role in energy metabolism, especially in deficient individuals

In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals