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Nat Commun (2017) 8:15074

Frequency: Once per day (subcutaneous), ideally 3060 minutes before bedtime

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Loading Phase (Weeks 1-4): 2 to 2.5 mg twice weekly (Monday/Thursday schedule) Maintenance Phase (Weeks 5+): 2 mg once every 7 to 14 days Administration: Subcutaneous injection, location flexible due to systemic distribution Total Cycle: 8 to 12 weeks with 4 to 8 weeks off between cycles The convenience of twice-weekly dosing during loading and weekly or biweekly dosing during maintenance fits easily into Retatrutide schedules