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The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion
Stress Load : Chronic stress pumps up cortisol, a hormone that puts the brakes on testosterone
This makes it a valuable therapeutic treatment in combating cognitive impairment and various brain disorders
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