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The lancet Diabetes Endocrinol 2021;9(10):653e62

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

Similar to managing high blood pressure or cholesterol, GLP-1 medications are often part of a lifelong approach to care for chronic conditions, as discussed in long-term therapy research

Convenient and easy to use: Our injection is quick and easy to administer, with no downtime or recovery required