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Unlike broad-spectrum medications that affect multiple systems at once, peptides are highly targeted

The HPG axis is responsible for the production of testosterone, the main sex hormone in males, other sex steroid hormones (dehydroepiandrosteroneDHEA, androstenedione, dihydrotestosterone, estrogen, and progesterone), peptide hormones (activin, inhibin, and follistatin, which are included in feedback mechanisms and spermatogenesis), production of spermatozoa (sperm cells), and sexual arousal (11, 15)

Intravenous mesna has been approved for this indication since 1988

Novel GLP-1-based Medications for Type 2 Diabetes and Obesity (Endocrine Reviews)