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Antioxid Redox Signal 9:2547 Tinkov AA, Bjrklund G, Skalny AV, Holmgren A, Skalnaya MG, Chirumbolo S, Aaseth J (2018) The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker

Similarly, trigonelline, an alkaloid present in hemp seed, coffee beans, oats, garden peas, and fenugreek seed, shows high basal Nrf2 activity that protects against etoposide- or TRAIL-induced apoptosis by elevating proteasomal gene expression (Panieri and Saso, 2019)

Precautions: Do not use with Direct Acids, Direct Vitamin C, Resveratrol and Ferulic Acid, Salicylic Acid, EUK, Retinoids and Strong Antioxidants

Still, stronger is not always better