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Pharmacokinetics (ADME) Absorption Well absorbed orally Rapid onset Distribution Highly protein bound (~99%) Metabolism Mainly hepatic metabolism Glucuronidation is significant Half-life About 23 hours But effect lasts longer due to enzyme inhibition Excretion Mainly via bile/feces Some renal excretion --- 5
Accessed May 2023 at 7
The new GLP-1 RA users, SGLT-2 inhibitor users and DPP-4 inhibitor users were defined as a first-time redemption for prescription of drugs with anatomical therapeutic chemical (ATC) codes A10BJ (GLP-1), A10BH (DPP-4 inhibitors) or A10BK (SGLT-2 inhibitors)
Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Kosnett MJ, Smith MT
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