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Microvascular complications burden (nephropathy, retinopathy and peripheral polyneuropathy) affects risk of major vascular events and all-cause mortality in type 1 diabetes: a 10-year follow-up study

However, chronic dosing (500mg twice daily for 4 weeks) did produce sustained elevation in erythrocyte glutathione and modest increases in skin GSH levels, likely because repeated administration saturates the transpeptidase enzymes and allows some intact GSH absorption

The usual 1-2 day gap before the next dose became nearly 4 days, and that was enough for the old patterns to fully reassert themselves

In particular, combination tablets such as DPP-4 inhibitors and metformin are easy to overlook, so caution is necessary