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They act as signals to tell the body what to do
By affecting all these cellular functions already impaired in aging individuals it could explain why older, comorbid patients have the most severe outcomes with COVID-19 (312) and stimulate the use of GSH and Nrf2 enhancers as well as develop new therapies to protect mitochondria
Under the acceleration of TGF-1, Nox4 mRNA is significantly upregulated and mediates the transformation of fibroblasts into myofibroblasts by activating TGF-1-Smad2/3 signaling, which leads to cardiac fibrosis
There was nonsignificant difference between the groups in gender, occupational status, or marital status as shown in Table 1
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