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Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)
This reduced weight and caloric intake may lower blood glucose
Incident users were required to have used oral antihyperglycemics as a proxy for T2DM during the pre-index period
The researchers also found that the benefits of GLP-1 therapy were especially pronounced in older adults, women, and certain racial subgroups
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