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In another study conducted in a rat model of metabolic syndrome, chronic treatment with liraglutide showed a greater increase in coronary vessel internal diameter than vehicle control (Sukumaran et al., 2020)

J Neurol Sci 124:8487 Dupuis L, Dengler R, Heneka MT et al (2012) A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis

Reduced liver weight or reduced steatosis-associated features in a diet-induced model should not be interpreted as proof of broad hepatic safety unless supported by appropriate histological assessment, serum chemistry, inflammatory markers, and study-duration-specific monitoring

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