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Because NNMT activity has been linked with obesity-related metabolic patterns, NNMT inhibition is studied as a way to improve metabolic efficiency in adipose tissue
Route changes exposure, and rat data cannot provide a safe conversion
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
SS-31 targets mitochondrial function directly
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