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Among small fish, especially, the medaka possesses an ability to hibernate, has high prolificacy, grows rapidly, is omnivorous and possesses carbohydrate/lipid metabolism functions similar to those found in mammals 5

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

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