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The companies that worked on this, then, in the 70s, the 80s, included Lilly and Novo, actually, but it wasnt until the Gila monster story kicked in in the late 80sI think this guy named John Eng in the Bronx was interested in why certain animals didnt need to eat very often and identified this mimic of the human peptide, but used for this lizards own purposes, exendin, which mimics GLP-1

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Using the estimated coefficients of the baseline characteristics that remained in the CV risk prediction model, a risk score could then be calculated for LEADER and extrapolated to other trials that measured the same baseline characteristics