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Understanding the Gauge (G) The term gauge refers to the diameter of the needle
It works through multiple mechanisms: Appetite regulation : Acts on brain centres controlling hunger and satiety, reducing food intake Gastric emptying : Slows the rate at which food leaves the stomach, promoting feelings of fullness Glucose regulation : Enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner Wegovy is administered as a once-weekly subcutaneous injection, with gradual dose escalation over 16 weeks (0.250.51.01.72.4 mg at 4-weekly intervals) to minimise gastrointestinal side effects
People with this variant were more likely to lose weight on GLP-1s
Holst JJ (1990) Peptidergic mechanisms in the pancreas
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