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Free radicals and oxidative stress are known to degrade collagen fibers through a process called collagenolysis

In summary, GLP-1 RAs, through weight loss and the reduction of pro-inflammatory cytokines [31, 33], could provide a complementary approach to standard therapies for HS, especially in patients with obesity [36]

Important for tissue healing and repair, though also a concern in cancer contexts where new vessels can supply tumors

These findings suggest that part of the clinical benefit of GLP-1RAs in PsO may derive not only from metabolic improvements but also from direct modulation of adipose-driven inflammatory pathways