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As mentioned above, several immune cells and inflammatory mediators seem to have a dual role in aggravating liver damage and promoting liver repair and regeneration, which, to some extent, affects scientists to translate this knowledge into effective treatment of AILI (with NAC being still the only FDA approved antidote)
Elevated cortisol promotes fat storage, particularly around the midsection, and can trigger emotional or stress-related eating that overrides the appetite suppression Zepbound provides
Additionally, the FDA grants statutory exclusivity periods that prevent generic competition regardless of patent status
Nat Commun 2015
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