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That said, weight loss in people with diabetes is still clinically meaningful and often leads to: Improved glucose control Reduced medication requirements Lower cardiovascular risk Better energy levels and mobility Important considerations GLP-1 medications are not cosmetic weight-loss drugs

European Medicines Agency (EMA) (2012) Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus

Finally, direct causal evidence in vivo remains limited

Attia G M, Almouteri M M, Alnakhli F T (August 31, 2023) Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility