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Ghosh, S., St Clair, R
5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed
It also appears to keep those cells alive longer by inhibiting programmed cell death, which depletes them
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