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Exenatide activated eNOS and NO production in endothelial cells, induced dose-dependent vasorelaxation, and mitigated high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo, effects which were reduced by AMPK (AMP-activated protein kinase) inhibition [86]
You might know it by its brand names, Ozempic (for type 2 diabetes) and Wegovy (for weight loss)
Despite their benefits, both medications come with potential side effects
Slightly more than half (53%) said they require patients to try non-pharmacological approaches before prescribing GLP-1/GIPs
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