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GnRH agonists, considered second-line therapy, can significantly reduce lesions but create a menopausal state

These can include: Digestive issues that could lead to dehydration and cause kidney damage Gastrointestinal issues like pancreatitis or gallbladder disease Low blood pressure Low blood sugar levels There is also a black box warning, the most serious kind from the FDA, on both medications for the risk of a certain rare type of thyroid cancer

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Most published evidence currently comes from laboratory and animal studies, with relatively few controlled human trials available