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First, compounded medications are not FDA-approved, meaning they have not undergone the rigorous testing for safety, efficacy, and manufacturing quality that brand-name drugs have

This is not just a pricing difference - it reflects fundamentally different regulatory pathways

This rapid increase has been argued to be due either to a release of IGF-1 stores in tissues or due to a proteolytic cleavage of IGFBP-3 either in the plasma or in tissue