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A randomized, double-blinded, placebo-controlled trial showed that 20 mg of melatonin for breast cancer before and during the first cycle of adjuvant chemotherapy modulated serum levels of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin kinase B (TrkB), suggesting a neuroprotective effect of melatonin [57]

Taken together, these results suggested that lactate is preferentially taken up by detached ER + breast cancer cells (may be dependent on ALDH status) and incorporated into the TCA cycle as a fuel