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However, there are notable challenges to the use of laccases for proximity labeling technology, most importantly that no laccase has previously been expressed and shown to be active in mammalian cells

Osman AA, Arslan E, Bartels M, Michikawa C, Lindemann A, Tomczak K, et al

ERCC1 forms a heterodimer with the endonuclease XPF, and this protein complex is responsible for the incision of the DNA strand processing the damage