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In patients with ME/CFS and Long COVID, advanced neuroimaging studies have consistently demonstrated abnormally low levels of brain glutathione coupled with highly elevated levels of ventricular lactate, a clear indicator of neuroinflammation and mitochondrial distress
On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (Russo et al., 2018)
g , Left, percent of cell number from Slc33a1 -knockout KP cells expressing a vector control or SLC33A1 cDNA treated with DMSO or tunicamycin for 4 days under indicated concentrations
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