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GHS-R1a activation triggers Gq/11 protein coupling, which stimulates phospholipase C, generates IP3 and diacylglycerol, and mobilizes intracellular calcium to drive GH exocytosis from secretory granules
The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise
Retatrutide, designated LY3437943, is a triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously
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