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Our research group investigated several ligands of BBB nutrient transport systems and the combination of the amino acid alanine and among them the tripeptide glutathione (A-GSH) was the most successful for targeting the BBB in case of nanovesicles [32, 33] or 3-armed poly(l-glutamic acid) (3-PLG) nanocarriers in BBB cultures and animals [24]

Monomeric L-arginine and L-lysine seem to be good acceptors, while L-alanine, L-serine, L-glutamine, and L-glutamic acids have been reported to be poor acceptors (Lee et al., 2017)

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