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A limitation of the study was the use of several assumptions in the modelling analysis, in lieu of available and appropriate clinical data, although assumptions were informed by published data and were chosen to balance clinical realism with modelling fairness
The most common dosages for weight loss are 2.4 mg once a week or 1.0 mg once a day
consult your provider before any dose changes
This relationship supports the hypothesis that much of tirzepatide's anti-inflammatory benefit may be mediated through weight loss rather than direct receptor-mediated anti-inflammatory signaling, though controlled studies specifically addressing this question are limited
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