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Third, as outlined above, interictal neuroimaging studies have described persistent structural and functional alterations of the thalamus and thalamo-cortical networks in migraine without aura [8, 34, 31, 35]

Peripherally, they improve insulin sensitivity, reduce hepatic lipotoxicity, and attenuate systemic and hepatic inflammation (Jones and Brierley, 2025

More recently, GLP-1 RA drugs have been approved for weight loss, cardiovascular disease, and chronic kidney disease

SURPASS-5 underscored its benefits for patients already on insulin glargine, while studies conducted in Japan, including SURPASS J-mono and SURPASS J-combo, reinforced its safety and efficacy in managing T2DM (46)