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IGF-1 LR3 in Stem Cell Self-Renewal Research Research has established that IGF-1 receptor signalling is necessary for human embryonic stem cell self-renewal, and that IGF-1 LR3 can substitute for native IGF-1 in stem cell cultures with increased potency and stability requiring lower concentrations for equivalent or superior biological effects compared to unmodified IGF-1
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This stress is shown by the overexpression of iNOS, an enzyme primarily involved in the mitochondrial lipid peroxidation, with consequent damage of the cell membrane, which is validated by the accumulation of intracellular MDA: a hallmark of lipoperoxidation
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