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[2] [1] The risk of hypoglycaemia is meaningfully increased when retatrutide is used alongside insulin or sulfonylureas, consistent with the established class precedent for GLP-1 receptor agonists (as documented in the SmPCs for tirzepatide and semaglutide)

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Zhang X, Zhang Z, Zhao Y, Jiang N, Qiu J, Yang Y, Li J, Liang X, Wang X, Tse G, Li G, Liu T (2017) Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits