Other reported neurobiological effects of ALCAR include modulation of: (1) brain energy and phospholipid metabolism
Thus, GLP-1R may be a potential link between DM and AD, and we look forward to discovering more about the mechanism of the link between these two diseases, as well as new applications of GLP-1R agonists in the treatment of AD
It also appears to help reduce symptoms of ADHD by influencing serotonin and dopamine levels in the brain, which can support better impulse control, focus, and motivation, particularly when mood and cognitive clarity are affected by stress
Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]