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Direct Cardiovascular Effects: GLP-1 receptor agonists like semaglutide may exert direct cardioprotective effects, including improving endothelial function, reducing oxidative stress, and modulating atherosclerotic processes

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Other documented adverse effects include injection site reactions, fatigue, hypoglycemia (particularly when used with insulin or insulin secretagogues), and increased heart rate

That means forging policies that reward innovation and uphold the public interest, so that when the next breakthrough therapy comes along (and it will, with continued public support), we dont repeat the same disconnect between scientific success and societal benefit.