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Interestingly, in this study, they did not report a significant change in patients weight or blood sugar control, suggesting that the mechanism by which psoriasis is improved may be independent from the GLP-1 medications mechanism of action for type 2 diabetes
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Published GLP-1 clinical research - including a real-world study published in Advances in Therapy (2025) covering nearly 10,000 patients - documented mean weight loss of 14.1% for semaglutide 2.4 mg and 16.5% for tirzepatide over one year
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