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It also emphasizes the importance of hydration and nutrition in mitigating these effects

HO-1 facilitates the breakdown of heme, resulting in the release of significant quantities of reactive iron ions, which then promote the Fenton reaction, ultimately producing lipid peroxides and causing ferroptosis in osteoblasts ( Figure 3 ) (124, 136)

Some studies were conducted in Asia and others only in Europe, precluding the application of the results to populations of different ethnic backgrounds

The pain and associated symptoms disrupt home, school and social lives, and youth with migraine are more likely to experience depression, anxiety and behavioural challenges 2