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, TLRs) expressed on the inflammatory M initiate the innate immune signaling pathways and trigger a variety of pro-inflammatory cytokines production, which in turn instructs a pro-inflammatory adaptive immune response involving primarily Th1 cells (204, 205)

Hoevenaars FPM, Wopereis S, Plugues M, La Terra P, Batchnarova N

Some of the fragments, for which X-ray structures were obtained, were found in the doorstop pocket expected to be critical for TGR inhibition and adjacent to the NADPH binding site (Fig