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Last Published 10.31.2025 Effective Date: 11.01.2025 This policy addresses the use of Ilaris (canakinumab) for the treatment of cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS), hyperimmunoglobulin D (Hyper-IgD) syndrome (HIDS)/mevalonate kinase deficiency (MKD), familial mediterranean fever (FMF), Stills disease, systemic juvenile idiopathic arthritis (SJIA) and gout flares

Parker BA, Thompson PD

[PMID: 9485455] PubMed record related to this compound for laboratory literature review

It affects 40 to 70 percent of users and often hits hardest during the first few weeks or upon increasing your dose