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Clinical studies of GLP-1 receptor agonists show that many individuals experience meaningful weight reduction over several months , with results building gradually Trusted Source Efficacy of GLP-1 RA Approved for Weight Management in Patients With or Without Diabetes: A Narrative Review Advances in Therapy Go to Source over time

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The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months