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Clinical Manifestations of Vitamin B12 Deficiency Although the classic hematologic expression of vitamin B 12 deficiency is a megaloblastic macrocytic anemia characterized by an elevated mean corpuscular volume and mean corpuscular hemoglobin, and a peripheral smear containing macroovalocytes and hypersegmented neutrophils, up to 28 percent of affected patients may have a normal hemoglobin level, and up to 17 percent may have a normal mean corpuscular volume
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The combination of direct nerve regeneration effects and systemic anti-inflammatory action makes ARA-290 potentially valuable for the complex inflammatory and neurological manifestations of sarcoidosis
Originally developed in Russia, early human and animal studies suggest that Selank may reduce anxiety and improve stress resilience, which are key factors that often contribute to relapse (Chaban et al., 2016)
