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A CM5 sensor chip (Cytiva) was used to immobilize recombinant human FBXO22
doi: 10.1073/PNAS.092672899 52 Garca-SezAJ
You mentioned gut, and I think its probably worth noting that, you know, the largest concentration of diamine oxidase is in the lining of the gut, meaning if you have any digestive issues, gastrointestinal inflammation, you immediately lose that, you know, frontline histamine-metabolizing layer, which also then leaves you more vulnerable to reactions to dietary histamines, because its DAO that would normally take care of those for you
No poor mucosal integrity weakens hormone signaling and increases inflammation, reducing GLP-1 effectiveness
