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Footnote Nonstandard Abbreviations and Acronyms AMPLITUDE-O Effect of Efpeglenatide on Cardiovascular Outcomes CKD chronic kidney disease eGFR estimated glomerular filtration rate FLOW Effect of Semaglutide Versus Placebo on the Progression of Renal Impairment in Subjects With Type 2 Diabetes and Chronic Kidney Disease GLP-1 glucagon-like peptide-1 Harmony Outcomes Albiglutide and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Cardiovascular Disease HR hazard ratio PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analysis PROSPERO International Prospective Register of Systematic Reviews REWIND Researching Cardiovascular Events With a Weekly Incretin in Diabetes RR risk ratio SGLT2 sodium glucose cotransporter 2 Supplemental Material File (circ_circulationaha-2024-071689_supp1.pdf) Tables S1 and S2 Figure S1 Download 103.72 KB REFERENCES 1

As we navigate through the complexities of peptide therapy, we will also highlight the importance of consulting healthcare professionals for personalized guidance

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