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Margins recommended in New Zealand (2013): Melanoma in situ: 510 mm Melanoma 2 mm: 20 mm Australian Clinical Practice Guidelines for the diagnosis and management of melanoma (updated 2018), recommend, where possible: Melanoma in situ: 5 mm, and wider margins if appropriate Melanoma 4 mm: 20 mm Systemic therapy If the melanoma is widespread, surgical treatment is not always successful in eradicating cancer

GLP-1 receptor agonists are mainly administered through the parenteral route due to poor oral bioavailability and degradation in the GI tract