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Potential losers include medical device companies focused on diabetes care and hip and knee replacements, packaged food companies that sell candy or other unhealthy snacks and companies that sell beer and other alcoholic beverages

This finding highlights not only the key role that mitochondrial metabolism has in modulating response and resistance to TS inhibitors, but the wider opportunity afforded to enhance TS inhibitor-mediated anti-cancer effects by targeting mitochondrial metabolism using metformin or other compounds with similar mitochondrial impact

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One large cohort reports almost 50% deceased patients [23, 25]