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[16] [18] Healthcare providers should weigh the anticipated benefits against potential risks and consider alternative routes or lower doses when appropriate

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Our projected 24% reduction in cardiovascular events in persons with overweight or obesity but without cardiovascular disease from tirzepatide compares favorably to the well-publicized SELECT trial published last year involving another weight-loss medication Wegovy (semaglutide 2.4 milligram), which was studied in persons with cardiovascular disease and showed a 20% reduction in future cardiovascular events, said Wong, who also previously published a similar analysis of semaglutide estimating an 18% risk reduction in persons without cardiovascular disease