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Because of these changes, bariatric surgery often leads to different outcomes, including weight loss of about 25% to 30% or more of total body weight, with long-term data showing more sustained results for many patients

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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)

Methylmalonic acid (MMA) test: Methylmalonic acid test detects elevated levels of MMA, a compound that increases when there is a deficiency of vitamin B12