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GHK-Cus anti-aging effects are attributed to its capacity to stimulate collagen synthesis, enhance fibroblast activity, and promote extracellular matrix remodelling

Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

The GIP component may actually buffer some of the gastrointestinal distress that GLP-1 activation alone produces

Humanin cellular stress protection Humanin is another mitochondrial-derived peptide, studied for protective effects against cellular stress