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In the SURPASS trials (type 2 diabetes), tirzepatide produced HbA1c reductions of 2.02.3% among the largest reductions ever documented for any antidiabetic medication
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A patient on Wegovy 2.4 mg who starts tirzepatide at 10 mg rather than 2.5 mg would be introducing a novel molecule at a dose far higher than the tolerability data support for initiators [1][6]
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